Download Applications of Ion Chromatography for Pharmaceutical and by Lokesh Bhattacharyya, Jeffrey S. Rohrer PDF

By Lokesh Bhattacharyya, Jeffrey S. Rohrer

This can be a complete resource of data at the software of ion chromatography (IC) within the research of pharmaceutical medicines and biologicals. This e-book, with participants from academia, pharma, the biotech undefined, and device production, offers the various views, adventure, and services of the concept leaders of IC in a entire demeanour. It explores power IC purposes in numerous points of product improvement and qc checking out. additionally, an appendix part provides info on serious actual and chromatographic parameters relating to IC and knowledge on present brands of IC structures, columns, and different components.Content:
Chapter 1 Ion Chromatography—Principles and purposes (pages 1–21): Lokesh Bhattacharyya
Chapter 2 Retention approaches in Ion?Exclusion Chromatography: a brand new standpoint (pages 23–47): Milko Novic and Paul R. Haddad
Chapter three Pulsed Electrochemical Detection in Ion Chromatography (pages 49–90): William R. Lacourse
Chapter four Suppressor layout and Detection for Ion Chromatography (pages 91–105): Kannan Srinivasan, Sheetal Bhardwaj, Rong Lin and Christopher Pohl
Chapter five Modelling and Optimization of Ion Chromatographic Separations of Pharmaceutically proper natural Ions (pages 107–133): Philip Zakaria, Greg Dicinoski, Melissa Hanna?Brown and Paul R. Haddad
Chapter 6 Ion Chromatography in Pharmaceutical Drug research (pages 135–157): Lokesh Bhattacharyya
Chapter 7 research for Impurities through Ion Chromatography (pages 159–174): Shreekant V. Karmarkar
Chapter eight Ion Chromatography research of Aminoglycoside Antibiotics (pages 175–192): Valoran P. Hanko and Jeffrey S. Rohrer
Chapter nine Use of Cation?Exchange Ion Chromatography within the research of prescribed drugs (pages 193–220): Christopher Pohl, Maria Rey and Rosanne Slingsby
Chapter eleven excessive functionality Ion Chromatographic research of Cholinergic Compounds: Carbachol and Bethanechol, and linked Degradation items (pages 237–245): David Trowbridge
Chapter 12 Ion Chromatographic research of prescription drugs for Authenticity and Adulteration (pages 247–257): David S. Jackson
Chapter thirteen Ion Chromatography of Drug Product Counter?Ions and different Ions in Drug items (pages 259–269): Brian M. De Borba and Jeffrey S. Rohrer
Chapter 14 pattern coaching concepts in Ion Chromatography for Pharmaceutical purposes (pages 271–283): Jay Gandhi
Chapter 15 Validation of Ion Chromatographic equipment (pages 285–308): Shreekant V. Karmarkar
Chapter sixteen Pharmacopeial functions of Ion Chromatography (pages 309–320): Ravi Ravichandran
Chapter 10 entire techniques for dimension of energetic Pharmaceutical elements, Counter?Ions, and Excipients utilizing HPLC with Charged Aerosol Detection (pages 221–236): Christopher Crafts, Bruce Bailey, Paul Gamache, Xiaodong Liu and Ian Acworth
Chapter 17 Glycan research by means of excessive functionality Anion alternate Chromatography with Pulsed Amperometric Detection (pages 321–338): Lokesh Bhattacharyya
Chapter 18 Monosaccharide research of Glycoproteins by means of High?Performance Anion?Exchange Chromatography with Pulsed Amperometric Detection (pages 339–350): Jeffrey S. Rohrer
Chapter 19 Two?Dimensional Ion Chromatography for Simultaneous decision of Amino Acids and Carbohydrates (pages 351–364): Petr Jandik and Jun Cheng
Chapter 20 tracking Protein N?Glycosylation Consistency utilizing HPAEC?PAD (pages 365–377): Carl Grey
Chapter 21 Oligosaccharide research by way of High?Performance Anion?Exchange Chromatography Hyphenated to built-in Pulsed Amperometric Detection and On?Line Ion?Trap Mass Spectrometry (pages 379–391): Cees Bruggink
Chapter 22 functions of Ion Chromatography in organic Product Analyses (pages 393–421): Alfred V. Del Grosso and Brandon Duong
Chapter 23 excessive functionality Anion?Exchange Chromatography with Pulsed Amperometric Detection (HPAEC?PAD) research of GBS Glycoconjugate Vaccines: From Fermentation to ultimate Product (pages 423–434): Stefano Ricci, Barbara Fabbri, Sara Giannini, Silvia Bernardini, Marcello Morelli and Sandro D'Ascenzi
Chapter 24 balance reviews and Characterization of Meningococcal A, C, Y, and W135 Glycoconjugate Vaccine (pages 435–447): Valeria Carinci, Alberto Bernardini, Cristiana Campa, Claudia Magagnoli, Francesca Beccai and Sandro D'Ascenzi

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Extra info for Applications of Ion Chromatography for Pharmaceutical and Biological Products

Example text

3b) was constant and was identical to the detector response occurring after the same eluent had been used to equilibrate the column from the water form. That is, the stationary phase fully loaded with the eluent acid released this acid at a concentration identical to that which had been used to load it. 2. Detector responses obtained during conversion of the column from the water form to (a) the sulfuric acid form or (b) the acetic acid form. Experimental conditions: analytical system DX-500 with IonPac ICE-AS1 analytical column, eluent flow rate 1 mL/min, column temperature was 30◦ C.

Medved AL, Ivanov AA, Shpigun OA. Ion-exclusion chromatography of organic acids: Regularities in the retention of aliphatic carboxylic acids. J. Anal. Chem. 1996;51:964–971. 13. Waki H, Tokunaga Y. Donnan exclusion chromatography: I. Theory and application to the separation of phosphorus oxoanions or metal cations. J. Chromatogr. 1980;201:259–264. 46 RETENTION PROCESSES IN ION-EXCLUSION CHROMATOGRAPHY: A NEW PERSPECTIVE 14. Kihara K, Rokushika S, Hatano H. Elution behavior of aliphatic carboxylic acids on a strong cation-exchange resin column.

In searching for an alternative IEC separation mechanism the following theoretical and experimental considerations should also be taken into account: (i) The substrate beads are composed of 8% cross-linked PS-DVB with an average diameter of approximately 7 μm. (ii) The PS-DVB resin is fully functionalized, having a total ion-exchange capacity of approx 5 meq/g of dry resin. As mentioned earlier, the complete functionalization means that there is one sulfonic group attached to each aromatic ring.

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