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124, 1 4 - 2 5 . 6. A n a g n o s t o p o u l o s , C , and Crawford, I. P. (1961). Proc. Nat. Acad. Sei. USA 47, 378-390. 28 DENNIS J. HENNER AND JAMES Α. HOCH 7. Anagnostopoulos, C , and Schneider-Champagne, Α. M. (1966). C. R. Ac ad. Sei. Paris Ser. D 262, 1311-1314. 8. Andersen, J. , and Ganesan, Α . T. (1975). J. Bacteriol. 121, 173-183. 9. , Fortunata, Α . , and Falaschi, A . (1976). Mol. Gen. Genet. 148, 9 - 1 7 . 10. Bachmann, B. , and Brooks, L. K. (1980). Microbiol. Rev. 44, 1-56. 11.
T h e y c o n c l u d e d t h a t d i c h o t o m o u s replication w a s not a result of initiation occurring earlier in time in relation to the previous initiation, but r a t h e r a result of the n o r m a l progression of the cells t o w a r d the next initiation event, w h e r e a s the rate of D N A replication w a s m u c h slower. In the case of t h y m i n e starvation, the n u m b e r of p r e m a t u r e initiations is limited b e c a u s e of a d e c r e a s e d rate of protein synthesis during starvation.
197, 1 9 9 - 2 0 1 . Zahler, S. Α . , Benjamin, L . , Glatz, B. , Winter, P. F . , and Goldstein, B. J. (1976). In "Microbiology, 1976" ( D . ), pp. 3 5 - 4 3 . American Society for Microbiology, Washington, D . C. 208. Zahler, S. Α . , Korman, R. , and Hemphill, H. E . (1977). J. Bacteriol. 129, 5 5 6 - 5 5 8 . 2 DNA Replication in Bacillus subtilis SCOTT WINSTON AND NOBORU SUEOKA I. IL III. IV. V. VI. Introduction Replication in Vivo A . Size and Circularity of the C h r o m o s o m e Β . Replication from a Fixed Origin C.