By Yoko Eguchi, Ryutaro Utsumi (auth.), Ryutaro Utsumi PhD (eds.)
This attention-grabbing booklet encourages many microbiologists and scholars to go into the recent global of sign transduction in microbiology. over the last decade, an unlimited volume of intriguing new details at the sign transduction pathway in micro organism has been dropped at mild. reviews on those advancements were prepare during this e-book, Bacterial sign Transduction: Networks and Drug objectives. the purpose of this e-book is to supply an incentive for graduate scholars, educational scientists, and researchers within the pharmaceutical to additional elucidate the TCS networks and observe them within the look for novel drugs.
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Extra resources for Bacterial Signal Transduction: Networks and Drug Targets
The side-chain ofthe phosphorylated His residue is extremely exposed to bulk solvent (Fig. The orientation ofthe His residue is apparently suitable for accepting the phosphoryl group from the catalytic domain in trans-autophosphorylation 1 and for subsequently donating it to its cognate RR. Catalytic Domain The structures of catalytic domain of HK have been solved for CheA,IO·11 PhoQ (E. coli Mg2+ sensor),'? EnvZ,18 NtrB (E. coli nitrate sensor)," and PrrB (Mycobacterium tuberculosis)20 (Figs. 3A to 3F).
Coli, Shigella, Enterobacter The PhoQlPhoP Regulatory Network tifSalmonella enterica 17 genesand display RpoS-dependent phenotypes, such as resistance to hydrogen peroxide, in response to the low Mit' signal sensed by the PhoQ protein. This activation entails binding of the PhoP protein to the iraP promoter, which stimulates iraP transcription. raP protein competes with RpoS for binding to the response regulator MviA (referred to in E. coli as RssB or SprE). raP titrates the MviA protein, allowing the free RpoS to reprogram RNA polymerase to transcribe RpoS-dependent promoters.
Bader Mw; Sanowar S. Daley ME et al. Recognition of antimicrobial peptides by a bacterial sensor kinase. Cell 2005; 122:461-472. 25. Prost LR. Daley ME, Le Sage Vet al. Activation of the bacterial sensor kinase PhoQ by acidic pH. Mol Cell 2007; 26:165-174. 26. Groisman EA, Mouslim e. Sensing by bacterial regulatory systems in host and nonhost environments. Nat Rev Microbiol2006; 4:705-709. 27. Gunn JS. Hohmann EL. Miller SI. Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP.