By Flemming Pociot (auth.), Bernhelm Booß-Bavnbek, Beate Klösgen, Jesper Larsen, Flemming Pociot, Erik Renström (eds.)
The insulin secreting β-cell is without doubt one of the so much really expert mobile varieties with various and multi-functional parts (genes, gene items, organelles and metabolites) and a mess of regulatory concepts based on inner and environmental signs. This ebook appears on the technological advances that make simultaneous detection of hundreds of thousands of organic variables attainable; at a considerable number of mathematical types and numerical simulations that objective to provide an explanation for significant features of the β-cell functionality; and on the problem to formulate a entire and strong version of the most networks of the underlying biochemical and actual tactics for diagnostic and healing use.
Read or Download BetaSys: Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells PDF
Similar biology books
The equipment of lifestyles is a trip into the sub-microscopic international of molecular machines. Readers are brought to the kinds of molecules equipped by means of cells, together with proteins, nucleic acids, lipids, and polysaccharides; then, in a sequence of full-color "watercolor" illustrations, which exhibit a component to a residing cellphone magnified by means of a million instances, the reader is guided in the course of the inside global of cells.
New waveguide results are thought of at the foundation on a number of variations for self-focusing of the residing cells of aquatic plant by way of laser beam irradiation. it really is learning the method of forming of the 'living multy-mode fiber-optic' into the line of laser's beam in water with movement of eco-friendly dwelling cells.
This e-book is a complete examine present wisdom and techniques utilized in a booming box. this is often simply the second one ebook of its variety, and does a superb activity of providing rules essentially to these simply beginning out within the box or to execs. it's not an informal learn, but when you're looking for a systematic reference, this ebook is for you.
This ebook constitutes the court cases of the eleventh overseas convention on Computational equipment in platforms Biology, CMSB 2013, held in Klosterneuburg, Austria, in September 2013. The 15 general papers incorporated during this quantity have been conscientiously reviewed and chosen from 27 submissions. They take care of computational types for all degrees, from molecular and mobile, to organs and full organisms.
- A New Biology for the 21st Century
- Cytoskeleton Methods and Protocols (Methods in Molecular Biology Vol 161)
- The Mouse Nervous System
- Glycobiology Protocols (Methods in Molecular Biology Vol 347)
- The Biology of Neuropeptide Y and Related Peptides
Additional resources for BetaSys: Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
Increased prevalence of obesity has been identified as the main environmental factor causing the worldwide explosion in the incidence of type 2 diabetes. However, it is also well established that type 2 diabetes exhibits strong inheritance. The identification of the molecular genetics of type 2 diabetes started in the early 1990s and turned out a most challenging task. The advent of the HapMap and novel high-throughput technologies enabled the development of genome-wide association scans (GWAS), which represent one of the main milestones in modern medical research.
American Diabetes Association (2009) Diagnosis and classification of diabetes mellitus. Diabetes Care 32(Suppl 1):S62–67 7. Cefalu WT (2009) Inflammation, insulin resistance, and type 2 diabetes: back to the future? Diabetes 58:307–308 8. Rhodes CJ (2005) Type 2 diabetes-a matter of beta-cell life and death? Science 307:380–384 9. Baptiste-Roberts K, Barone BB, Gary TL, Golden SH, Wilson LM, Bass EB, Nicholson WK (2009) Risk factors for type 2 diabetes among women with gestational diabetes: a systematic review.
Insulin is formed in the endoplasmic reticulum (ER) in its precursor form proinsulin, which is later converted by a series of peptidase cleavage by prehormone convertases 1 and 3 (PC2 and PC1/3, respectively) into mature insulin [7, 106]. These changes start already in the Golgi apparatus, where the insulin granules are formed by budding. e. granule precursors) in the ER to the Golgi and further transport of formed granules to the plasma membrane is controlled by a family of small regulatory GTP-binding Rab proteins [29, 107].