Download BetaSys: Systems Biology of Regulated Exocytosis in by Flemming Pociot (auth.), Bernhelm Booß-Bavnbek, Beate PDF

By Flemming Pociot (auth.), Bernhelm Booß-Bavnbek, Beate Klösgen, Jesper Larsen, Flemming Pociot, Erik Renström (eds.)

The insulin secreting β-cell is without doubt one of the so much really expert mobile varieties with various and multi-functional parts (genes, gene items, organelles and metabolites) and a mess of regulatory concepts based on inner and environmental signs. This ebook appears on the technological advances that make simultaneous detection of hundreds of thousands of organic variables attainable; at a considerable number of mathematical types and numerical simulations that objective to provide an explanation for significant features of the β-cell functionality; and on the problem to formulate a entire and strong version of the most networks of the underlying biochemical and actual tactics for diagnostic and healing use.

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Additional resources for BetaSys: Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells

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Increased prevalence of obesity has been identified as the main environmental factor causing the worldwide explosion in the incidence of type 2 diabetes. However, it is also well established that type 2 diabetes exhibits strong inheritance. The identification of the molecular genetics of type 2 diabetes started in the early 1990s and turned out a most challenging task. The advent of the HapMap and novel high-throughput technologies enabled the development of genome-wide association scans (GWAS), which represent one of the main milestones in modern medical research.

American Diabetes Association (2009) Diagnosis and classification of diabetes mellitus. Diabetes Care 32(Suppl 1):S62–67 7. Cefalu WT (2009) Inflammation, insulin resistance, and type 2 diabetes: back to the future? Diabetes 58:307–308 8. Rhodes CJ (2005) Type 2 diabetes-a matter of beta-cell life and death? Science 307:380–384 9. Baptiste-Roberts K, Barone BB, Gary TL, Golden SH, Wilson LM, Bass EB, Nicholson WK (2009) Risk factors for type 2 diabetes among women with gestational diabetes: a systematic review.

Insulin is formed in the endoplasmic reticulum (ER) in its precursor form proinsulin, which is later converted by a series of peptidase cleavage by prehormone convertases 1 and 3 (PC2 and PC1/3, respectively) into mature insulin [7, 106]. These changes start already in the Golgi apparatus, where the insulin granules are formed by budding. e. granule precursors) in the ER to the Golgi and further transport of formed granules to the plasma membrane is controlled by a family of small regulatory GTP-binding Rab proteins [29, 107].

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